The anti-wrinkle time patch, which contains a patented hybrid protein ingredient, a new botulinum toxin material, has 700 conical microneedles that penetrate into the skin painlessly and deliver active ingredients directly, TDDS(Transdermal drug delivery system), to promote skin regeneration and fill in fine wrinkles. Sodium hyaluronate crosspolymer-2 component has a higher moisture supply than hyaluronic acid and helps other active ingredients to be delivered into the skin continuously for a long time, and also increases efficiency. Simply attaching and removing the needle patch for a certain period of time can effectively help lift, remove wrinkles, and improve dark circles.